"I forgot about commenting back on the Alports questions you posed. Dr. Cade diagnosed my father-in-law in the late 1960's. My father-in-law was a succesful attorney. Dr. Cade sent them to the only place in the country at that time for…"
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Stephen I. Hsu, MD, PhD
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- Gainesville, FL
- United States
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Stephen I. Hsu, MD, PhD's Groups
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Innovation Gainesville
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Stephen I. Hsu, MD, PhD's Page
Latest Activity
Stephen I. Hsu, MD, PhD commented on Cris Johnsrud's event NIH SBIR Phase I grant writing boot camp"I am planning to submit SBIR grants for both the NIH and the Bankhead-Coley Cancer Research Program (FL state). Having never written an NIH grant in this format I would benefit greatly from attending the NIH SBIR Phase 1 bootcamp.…"
Stephen I. Hsu, MD, PhD is attending Cris Johnsrud's eventNIH SBIR Phase I grant writing boot camp at SFC CIED
September 24, 2011 to September 25, 2011
This is a pilot 2-day hands-on, guided grant writing workshop in a comfortable and confidential atmosphere for a select few companies and PIs interested in submitting a Phase I SBIR grant proposal to NIH by the December 5 deadline. Participants will leave the retreat with a complete draft written Phase I proposal.
Stephen I. Hsu, MD, PhD posted a status"Steve Hsu is representing Prometheon Pharma as an invited "pitcher" for the GAIN Fast Pitch event."
Stephen I. Hsu, MD, PhD posted a status"Flight attendant on Delta out of Gainesville refused to just let me put cell on "Airport Mode." Insisted I power down my phone. Make sense?"
Stephen I. Hsu, MD, PhD posted a status"Has anyone ever seen a book or article or commentary specifically about the role of "common sense" and/or intuition in creative innovation?"
Stephen I. Hsu, MD, PhD posted a status"Yesterday, a student ask me, "Dr. Hsu, it's amazing how you are able to think outside the box." I blurted out, "What box?""
Michelle Nguyen left a comment for Stephen I. Hsu, MD, PhD"Thank you Dr.Hsu. Yeah "Elley" is just a nickname some of my friends call me; it's a little bit more original than "Michelle" I suppose. I was born in San Jose, California; however, my parents came to the USA…"
Stephen I. Hsu, MD, PhD posted a status"Keith, you always find the most amazing examples to enlighten and to inspire. The importance of leadership is another lesson from the succes"
Stephen I. Hsu, MD, PhD left a comment for Michelle Nguyen"Loks great, Elley. I'm a bit slow. I just figured out that Elley is derived from Michelle. Were you born in the US or in Vietnam? I was born in Taiwan, raised by my grandparents from 6 months onwards (mom and dad went to…"
Stephen I. Hsu, MD, PhD posted a status"Welcome to Helen Goh, the new Chief Communications Officer for newly launched biotech Prometheon Pharma, LCC"
Stephen I. Hsu, MD, PhD posted a status"Welcome to Michelle Nguyen, website designer for our recently launched biotech company Prometheon Pharma, LLC"
Stephen I. Hsu, MD, PhD left a comment for Keith E. McInnis"That is great that you are re-starting Aikido practice. Actually, Huffman Sensei was not teaching Iaido until I contacted him in 2008/2009 to inquire about finding a teacher in Gainesville, since I had been undergoing intensive practice in Boston…"
Keith E. McInnis left a comment for Stephen I. Hsu, MD, PhD"An important thread is starting on this topic of Ai(harmony)Ki(energy)Do(way). Look at ThomasHuffman's Gainnet page (Aikido of Gainesville). I re-started my Aikido training recently and I am over 40. I also train Iaido (very new to…"
Profile Information
- Status
- Entrepreneur, Executive, Consultant
- Company Name
- Prometheon Pharma, LLC
- Title
- CEO/CSO
- Industry
- Biotechnology
- Who is your mentor and mentee?
- Phoebe Cade Miles, Randy Scott, Jamie Grooms, Roger Mazze (International Diabetes Center) and other GAIN and GTEC members (mentors)
- University/College
- Williams College/Seattle University, BSc (summa cum laude) in Chemistry; Albert Einstein College of Medicine, MD, PhD (NIH Medical Scientist Training Program Scholar in Molecular Pharmacology)
- Company website
- http://www.sidmartinbio.org/resident-client-companies/
- Professional Experiences & Goals
- Harvard Medical School-trained MD-PhD clinician-scientist and inventor, who opened a lab/office as a resident company, Prometheon Pharma, LLC, at the Sid Martin Biotechnology Development Institute on August 20, 2012. Prometheon Pharma, LLC ("Illuminating the Path from Discovery to Health") is developing a proprietary licensed technology for delivery of large molecule drugs such as insulin with a simple patch (just like an estrogen patch). Academically based since July 2007 at the UF College of Medicine as the R. Glenn Davis (DCI) Endowed Professor of Clinical and Translational Medicine in the Division of Nephrology (same division in which Dr. Bob Cade was a faculty member when he and his team invented Gatorade); I will be on "sabbatical" after October 29, 2012 to devote 100% effort on building Prometheon. My goals for Prometheon Pharma are to develop a business model and value propositions that to develop novel, affordable, safe, effective and non-invasive therapies for common diseases and that will have global impact on large populations in both high-resource (developed countries) and low-resouce (developing countries) settings.
- Specialties in Your Industries of Expertise
- I am the CEO and CSO of Prometheon Pharma, LLC. I am also the Chief Clinical Officer for Quantitative Medicine and I am a Consultant for the International Diabetes Center & Mayo Clinic (MN). Research specialties in molecular genetics, molecular and cell biology, animal models of human disease, global health and population-based screening for early disease, and novel drug patch technologies. Clinical specialties in internal medicine, nephrology and endocrinology.
My focus at Prometheon Pharma related to addressing the global pandemic of obesity and obesity-related conditions (insulin resistance, type 2 diabetes, high cholesterol, heart disease, stroke, vascular disease, kidney failure, obstructive sleep apnea and respiratory disease, fatty liver failure, etc) is to create a flagship long-acting insulin patch [TopixDM insulin glargine (LANTUS) patch] as the first of many product lines of patches that can delivery large molecule drugs and small chemical drugs that have not been possible to deliver passively across the skin using standard patch technology. We are also developing a new class of anti-obesity drugs that therapeutically targets the function of a novel master regulatory protein that regulates metabolism and energy balance based on recent discoveries by my research team. I have commercialized a novel antibody for prognostic testing for expression of a cancer-associated oncoprotein.
Our focus at Prometheon Pharma related to chemotherapy and drug delivery formulations is on developing the first non-invasive therapy for treating early cervical lesions that would otherwise progress to cervical cancer ("Say goodbye to the scalpel!"). We approached the "problem" of how to create a self-administered single-dose topical therapy that can address the global epidemic of human papillomavirus-associated cervical lesions in order to offer a non-invasive, simple to use, cost-effective, safe and effective that would work equally well in developed and developing countries (85% of cervical cancer deaths are in underdeveloped countries and other low-resource settings in the developed world). In wealthy countries, this novel therapy will out-compete and make invasive treatments obsolete for treatment of pre-cancerous cervical dysplasia.
I hold approved or provisional patents for a new cancer chemotherapeutic drug, a novel biopolymer drug delivery formulation for transdermal or transmucosal delivery of large molecule injectable drugs such as insulin (making needles obsolete), and a newly identified protein by my research team that is a therapeutic target for developing a new class of anti-obesity drugs that would allow an individual to eat as much fat and other forms of caloric intake without ever getting fat (mice in which the gene for this protein has been deleted are completely resistant to diet-induced obesity, type 2 diabetes and elevated cholesterol; you cannot make them fat).
Prometheon Pharma, LLC has filed a provisional patent through the UF Office of Technology and Licensing. Four additional patents are being filed by Prometheon Pharma as a private company.
- How did you hear about GAINnet and what are your interests?
- I led a team that was a "Sweet Sixteen" semi-finalist in the 2011 Cade Prize for Innovation contest and a Final Four in 2012. I am creating a Prometheon Pharma, LLC business model and value propositions to advance the development of novel, affordable, safe, effective and non-invasive therapies for common diseases and that will have global impact on large populations in both high-resource (developed countries) and low-resouce (developing countries) settings.
Stephen I. Hsu, MD, PhD's Blog
Launch of Prometheon Pharma, LLC (Leveraging on the Paradigm of a Private-Public Partnership)
Posted on July 22, 2011 at 4:30am 0 Comments 1 Like
“Like the mythological Greek god Prometheus who gave mankind the precious gift of fire, we are dedicated to developing novel therapeutics that address urgent and unmet global healthcare needs for the new millennium. Our goal is to offer patients the choice of non-invasive…
Comment Wall (4 comments)
- At 4:34pm on August 20, 2011, Keith E. McInnis said…
I forgot about commenting back on the Alports questions you posed. Dr. Cade diagnosed my father-in-law in the late 1960's. My father-in-law was a succesful attorney. Dr. Cade sent them to the only place in the country at that time for transplant-Indianapolis IN. Two transplants failed. He lived as a home hemodialysis patient, father of 4 and full-time private practice attorney for over 30 years. He began to experience hearing loss in his late 20's and was dependent upon hearing aids by his mid 30's. It kept him from accepting an offer to be a Judge locally as he was afraid he would miss something in a trial. My wife has Alports and some hearing loss in the mid-ranges(mild). My eldest son (about to be 13) has Alports. He has fine hearing now but we expect his hearing to begin to decline around the age of 20. He knows this and we take extra efforts to work on his speech articulation, vocabulary, enunciation and feedback awareness as well as good listening/attention habits methods etc. He knows all about his Alports.He is not kept in the dark and therefore not afraid. Dr. Cade saved my father-in-laws life and followed him for over a decade. Because of Dr. Cade all the children in the family were followed closely regarding renal function. My wife has taken care to not over-stress herself or her renal system. Having children was a very difficult decision at many levels and presented special high risk challenges.Thank you for the dedication to science and compassion you exhibit daily. For all of our children you do make a difference.
- At 9:46pm on July 20, 2011, Michelle Nguyen said…
- Thank you Dr.Hsu. Yeah "Elley" is just a nickname some of my friends call me; it's a little bit more original than "Michelle" I suppose. I was born in San Jose, California; however, my parents came to the USA as refugees to escape the Vietnam War. Wow! That must have been a difficult transition at that age! Did/do you miss Taiwan a lot? My father went through a similar experience. My great aunt raised him for most of his life. During the war he had to leave the family behind, but eventually reunited with them in the US.
- At 5:44pm on July 18, 2011, Keith E. McInnis said…
- An important thread is starting on this topic of Ai(harmony)Ki(energy)Do(way). Look at ThomasHuffman's Gainnet page (Aikido of Gainesville). I re-started my Aikido training recently and I am over 40. I also train Iaido (very new to me) I have the privilege of training with my two sons (age 11 and 12). Huffman Sensei and I are discussing an Aikido seminar for Gainnet members. So many seminars are what I call "butt-based" i.e. the participants sit through the seminar and try to learn how to do. It is akin to learning to swim by reading about swimming. So we will do an Aikido seminar which is active and philosophical. We have adult students at Aikido of Gainesville age range from 19 to nearly 60. Look at Tom Huffman's Gainnet profile to fully appreciate the lineage of his teaching. It doesn't even include his service as a US Marine of exemplary accomplishments.
- At 11:04am on July 17, 2011, Keith E. McInnis said…
Welcome to GAINnet! Your logo and tag line are nicely done. My speciality is communications technologies though I have a bit of experience in medical products and research (and law enforcement). My friend has a local private medical practice which has a weight loss program. He is also UF instructional MD. Dr. Cade diagnosed my father-in-law with Alports syndrome in the late 1960's. My father-in-law lived successfully on home hemo dialysis for 29 1/2 years while maintaining a law practice, fathering 4 children and 8 grand children. My 12 year old son has Alports. It is an unusual genetic disorder unlikely to be amenable to treatment--transplant is the only treatment. He should be fine until his 30's. As a former deputy sheriff I can relate a story which your product ideas may one day address. I worked with a deputy who while on patrol in uniform (also on the swat team) who had to inject himself 2-4 times/shift. He is in his late 20's and had perfect health until the onset of his diabetes. How could a 'patch' type delivery system (that sounds like what you are looking at) help in such a situation?
Welcome, congrats and I look forward to meeting you
Sincerely,
Keith E. McInnis
keithmcinnis@gmai.com
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